DBCO Acid is an amine-reactive non-activated building block used for derivatizing amine-containing molecule in the presence of activators (e.g. EDC, or HATU) through a stable amide bond. Short spacer arm adds minimal mass to modified molecules (305.11 daltons).
DBCO reagents are the most commonly used substrates for copper-free click chemistry. DBCO compounds react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.